Senior Research Associate Gene Delivery and Editing Technology

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Editing and Delivery Technology group is seeking an enthusiastic, self-driven Senior Research Associate who will be the key contributor with focus on transforming novel editing and delivery technologies from benchtop protocols to at-scale operations compatible with T-cell manufacturing platforms for therapeutic drug products. To be able to conduct technology validation and qualification to support process development, the individual will have to develop deep understanding of Juno’s existing proprietary T-cell manufacturing platforms and keen insight of how to improve them by introducing new technologies. The desired candidate is also expected to have excellent analytical abilities and DOE experience.

Primary Responsibilities

Support evaluation and validation of new technologies from bench-top to at-scale operations for T-cell manufacturing platforms.

Execute and coordinate experiments and assays in a timely manner and with sense of urgency.

Analyze the assay readouts and experimental data for troubleshooting and to discover potential levers for improvement.

Maintain communications with stakeholders to ensure the developed technologies meeting product and platform requirements.

Support technology development and on-going activities with external collaborators and service providers (CMOs, CROs)

Prepare samples/materials and track/maintain their sources to support experiments (cells, nucleic acids, protein-nucleic acid complexes and necessary reagents)

Maintain accurate and detailed laboratory notebook and documentation

Author technical reports and operating procedures

Basic Qualifications

B.S. in Molecular and Cellular Biology, Bioengineering, Virology, Biochemistry, or any biological sciences disciplines

4 years of bio/pharmaceutical industry experience in technology development or process validation

4 years of industry experience in primary cell culture, 2 years in primary human T-cells is preferred

2 years of industry experience in electroporation or any transfection/transduction (viral vectors or chemical reagents) techniques

Experience with BD Flow Cytometer instrumentation (FACSCanto, Fortessa, Symphony, Aria, etc.) and analysis software (FlowJo, FACSDiva, FCSExpress, etc.)

DOE methodology and statistical software (JMP, R, Spotfire, Prism, etc.)

Independently motivated to accomplish given tasks and work in teams

Ability to communicate clearly and concisely through oral presentations and technical writing

Preferred Qualifications

Knowledge and experience of cellular assays (e.g. cytokine, cytotoxicity, proliferation, exhaustion, or etc.) is a plus

Experience with Lentivirus and Adeno-associated virus is a plus

Experience with CAR-T production process is a plus

Experience with process qualification and validation is a plus

Hands-on user experience with any commercial microfluidic-based analytical or liquid-handling systems (e.g. Fluidigm, 10X genomics, Mission Bio, Formulatrix, etc.)

Ability to work collaboratively in a cross-functional scientific environment

Knowledge and concepts of state-of-the-art development of cell therapies

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com